Brain Rhythms Connect Impaired Inhibition to Altered Cognition in Schizophrenia
نویسندگان
چکیده
منابع مشابه
Brain Rhythms Connect Impaired Inhibition to Altered Cognition in Schizophrenia
In recent years, schizophrenia research has focused on inhibitory interneuron dysfunction at the level of neurobiology and on cognitive impairments at the psychological level. Reviewing both experimental and computational findings, we show how the temporal structure of the activity of neuronal populations, exemplified by brain rhythms, can begin to bridge these levels of complexity. Oscillation...
متن کاملCircadian rhythms and cognition in schizophrenia.
Cognitive impairment is a core feature of schizophrenia. Evidence in this Journal suggests that disrupted circadian synchronisation of sleep-wake phases may be one cause. Circadian synchronisation depends on the external input of light-dark cues and the integrity of central nervous system circadian oscillators; these may represent new interventional targets to improve cognition.
متن کاملMultiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms.
Small assemblies of hypothalamic "parvocellular" neurons release their neuroendocrine signals at the median eminence (ME) to control long-lasting pituitary hormone rhythms essential for homeostasis. How such rapid hypothalamic neurotransmission leads to slowly evolving hormonal signals remains unknown. Here, we show that the temporal organization of dopamine (DA) release events in freely behavi...
متن کاملRectifying disordered brain dynamics to improve cognition in schizophrenia.
Although most of us are more familiar with the spectacular psychotic symptoms, such as hallucinations and delusions, that characterize schizophrenia, it is the cognitive deficits that drive much of the disability seen in this illness, serving as a “glass ceiling” that limits social and occupational functioning in patients with the illness (1). Impaired cognition is largely unresponsive to antip...
متن کاملAltered global brain signal in schizophrenia.
Neuropsychiatric conditions like schizophrenia display a complex neurobiology, which has long been associated with distributed brain dysfunction. However, no investigation has tested whether schizophrenia shows alterations in global brain signal (GS), a signal derived from functional MRI and often discarded as a meaningless baseline in many studies. To evaluate GS alterations associated with sc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2015
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2015.02.005